Advances in the Nutritional Approach to Asthma & Allergies The Natural Inhibition of the 5-Lipoxygenase and Leukotrienes: AKBA- A neglected opportunity to promote health
ثبت نشده
چکیده
The 5-LO enzyme works on the arachidonate substrate to produce the “misery” of the leukotrienes. 3 These potent pro-inflammatory eicosanoids are in turn abundantly involved in over 35 chronic conditions including: asthma, allergies, colitis, arthritis, gastric disorders (promote ulcer formation, stimulate acid secretion, etc), scleroderma, psoriasis, atopic dermatitis, neurological diseases, and so on. 4
منابع مشابه
The Role of Leukotrienes in Respiratory Tract and Asthma
Polyunsaturated fatty acids play a role as precursors of biologically active compounds that can act as mediators or modulators of various cell functions. Thus three main groups of derivatives the prostaglandins, the thromboxanes, and recently discovered leukotrienes are formed by oxygenation and further transformation of various polyunsaturated fatty acids of which arachidonic acid plays t...
متن کاملطراحی، سنتز، مطالعه داکینگ مولکولی و ارزیابی بیولوژیکی مشتقات هتروآریل 2-فنوکسی پیریدین -3-ایل بهعنوان مهارکننده آنزیم لیپواکسیژناز
Introdution: Lipoxygenase enzyme is responsible for biosynthesis of leukotrienes that possess various pharmacological effects in the body. The beneficial therapeutic effects of lipoxygenase inhibitors have been proved in some diseases such as asthma, cancer and Alzheimer’s disease. So, the lipoxygenase inhibitors could be used in the treatment of some diseases and pathological conditions. In th...
متن کاملInhibition of 5-Lipoxygenase inhibitor zileuton in high-fat diet-induced nonalcoholic fatty liver disease progression model
Objective(s): Arachidonic Acid/5-lipoxygenase (AA/5-LOX) pathway connects lipid metabolism and proinflammatory cytokine, which are both related to the development and progression of nonalcoholic fatty liver disease (NAFLD). Therefore, the present study was designed to investigate the role of AA/5-LOX pathway in progression of NAFLD, and the effect of zileuton, an inhibitor of 5-LOX, in this mod...
متن کاملThe Inhibitory Effect of KCN, NaN3 and some Bivalent Ions on Lipoxygenase Activity of the Purified Human Placental
Lipoxygenase(LOX) catalyzes irreversible transfer of oxygen molecule to Arachidonic and Linoleic acid to produce 13 Hydroproxy Octadecadienoic acid. Recent studies showed the involvement of Lipoxygenase products, leukotrienes, in inflammations and Lipoxygenase pathways acts as mediators of early inflammatory events in atherosclerosis. The aim of the present study was purification and characteri...
متن کاملAcetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I.
Antiproliferative action of different pentacyclic triterpenes has repeatedly been reported, and some lipoxygenase inhibitors have been shown to induce cell death in various cell systems. Acetyl-11-keto-beta-boswellic acid (AKBA) is a pentacyclic triterpene that inhibits 5-lipoxygenase in a selective, enzymedirected, nonredox, and noncompetitive manner. To investigate a possible effect of AKBA o...
متن کامل